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| 25.10.2010 | ||||
| 02:07 | D1 Regular Season | Los Angeles Galaxy | 2-1 | FC Dallas |
| 24.10.2010 | ||||
| 22:10 | D1 Regular Season | Columbus Crew | 3-1 | Philadelphia Union |
| 05:07 | D1 Regular Season | Chivas USA | 1-4 | Chicago Fire |
| 03:07 | D1 Regular Season | Colorado Rapids | 2-2 | Real Salt Lake |
| 02:37 | D1 Regular Season | Kansas City Wizards | 4-1 | San Jose Earthquake |
| 01:45 | D1 Regular Season | DC United | 2-3 | Toronto FC |
| 23.10.2010 | ||||
| 22:05 | D1 Regular Season | Houston Dynamo | 2-1 | Seattle Sounders |
| 22.10.2010 | ||||
| 01:50 | D1 Regular Season | New York Red Bulls | 2-0 | New England Revs |
| 21.10.2010 | ||||
| 04:07 | D1 Regular Season | San Jose Earthquake | 3-0 | Chivas USA |
| 17.10.2010 | ||||
| 04:37 | D1 Regular Season | Los Angeles Galaxy | 1-3 | Colorado Rapids |
| 04:07 | D1 Regular Season | San Jose Earthquake | 0-1 | Houston Dynamo |
| 03:07 | D1 Regular Season | Real Salt Lake | 2-0 | FC Dallas |